PXD036472

PXD036472 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of urinary small extracellular vesicles deciphers the molecular signature of children with viral pneumonia：a pilot study
Description	There is evidence that small extracellular vesicles (sEV) play a vital role in immune responses to viral and bacterial infection. Characteristics of urinary sEV, however, from pediatric patients with pneumonia remain to be ill-defined. In this study, we isolated sEV from urines of children with viral pneumonia or Mycoplasma pneumoniae pneumonia and healthy children and performed label-free proteomic analysis of these vesicles and identified viral-specific differentially expressed proteins compared with healthy children. Results of functional enrichment analysis suggest that the proteomic profiles of urinary sEV serve as the basis for understanding the fundamental biology of infection in children with viral pneumonia.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:58:03.836.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dongrui Ji
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-02 06:33:51	ID requested
1	2023-01-12 19:33:39	announced
⏵ 2	2023-11-14 08:58:04	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Pneumonia,Pediatrics，Infection，Extracellular vesicle，Proteomic, Immunology

Lin Yang
contact affiliation	Department of Clinic Laboratory, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
contact email	lynyang73@163.com
lab head
Dongrui Ji
contact affiliation	Wayen Biotechnologies
contact email	878137865@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD036472
     1. Label: PRIDE project
     2. Name: Proteomic profiling of urinary small extracellular vesicles deciphers the molecular signature of children with viral pneumonia：a pilot study