PXD036326 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Arterial-Venous Endothelial Cell Cycle Proteins Differential Expression |
Description | HUVEC-FUCCI cells were used to demonstrate that different endothelial cell cycle states provide distict windows of opportunity for gene expression in response to extrinsic signals. HUVEC-FUCCI were FACS-isolated into three different cell cycle states. Peptide digests from the resulting lysates showed differentially expressed proteins among the three cell cycles. These studies show that endothelial cell cycle state determines the propensity for arterial vs. venous fate specification. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:32:35.301.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Erin Jeffery |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-26 07:29:30 | ID requested | |
1 | 2022-10-25 06:31:09 | announced | |
⏵ 2 | 2023-11-14 07:32:41 | announced | 2023-11-14: Updated project metadata. |
3 | 2023-11-14 08:29:38 | announced | 2023-11-14: Updated project metadata. |
Publication List
Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba M, Sheynkman GM, Walsh K, Hirschi KK, Endothelial cell cycle state determines propensity for arterial-venous fate. Nat Commun, 13(1):5891(2022) [pubmed] |
Laufs U, La Fata V, Plutzky J, Liao JK, Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation, 97(12):1129-35(1998) [pubmed] |
Keyword List
submitter keyword: proteomics, proteogenomics, early G1, S/G2/M, endothelial cells,HUVEC, late G1, cell cycle |
Contact List
Dr. Gloria Sheynkman |
contact affiliation | Department of Molecular Physiology and Biological Physics University of Virginia School of Medicine Charlottesville, VA, USA 22908 |
contact email | gs9yr@virginia.edu |
lab head | |
Erin Jeffery |
contact affiliation | University of Virginia, Department of Molecular Physiology and Biological Physics |
contact email | edf4n@virginia.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036326
- Label: PRIDE project
- Name: Arterial-Venous Endothelial Cell Cycle Proteins Differential Expression