PXD035829-1

PXD035829 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
Description	To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBUMIN+ hepatocytes (CLiP-Hep) cells. To systematically interrogate the early regulatory events of hepatic reprogramming, we profiled the Phosphoproteome and proteome in human dermal fibroblasts (HDFs) at 2.25 days (FHH-2.25d) and 5 days (FHH-5d) after infection of lenti-virus encoding three liver-specific transcription factors, FOXA3, HNF1A and HNF4A (FHH). In this analysis, HDF infected with lenti-virus expressing GFP for 2.25 days (GFP) were used as control.
HostingRepository	iProX
AnnounceDate	2022-08-05
AnnouncementXML	Submission_2022-08-05_09:32:26.897.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yangyang Yuan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-05 09:31:02	ID requested
⏵ 1	2022-08-05 09:32:27	announced
2	2023-03-01 22:59:27	announced	2023-03-02: Update publication information.

Dataset with its publication pending

submitter keyword: Phosphoproteome, proteome, hepatocyte maturation, hepatic reprogramming, TMT

Yu Xue
contact affiliation	Huazhong University of Science and Technology, Wuhan, China
contact email	xueyu@hust.edu.cn
lab head
Yangyang Yuan
contact affiliation	ShanghaiTech University, Shanghai, China
contact email	yuanyy@shanghaitech.edu.cn
dataset submitter

iProX dataset URI