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PXD035829-1

PXD035829 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
DescriptionTo identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBUMIN+ hepatocytes (CLiP-Hep) cells. To systematically interrogate the early regulatory events of hepatic reprogramming, we profiled the Phosphoproteome and proteome in human dermal fibroblasts (HDFs) at 2.25 days (FHH-2.25d) and 5 days (FHH-5d) after infection of lenti-virus encoding three liver-specific transcription factors, FOXA3, HNF1A and HNF4A (FHH). In this analysis, HDF infected with lenti-virus expressing GFP for 2.25 days (GFP) were used as control.
HostingRepositoryiProX
AnnounceDate2022-08-05
AnnouncementXMLSubmission_2022-08-05_09:32:26.897.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYangyang Yuan
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-05 09:31:02ID requested
12022-08-05 09:32:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Phosphoproteome, proteome, hepatocyte maturation, hepatic reprogramming, TMT
Contact List
Yu Xue
contact affiliationHuazhong University of Science and Technology, Wuhan, China
contact emailxueyu@hust.edu.cn
lab head
Yangyang Yuan
contact affiliationShanghaiTech University, Shanghai, China
contact emailyuanyy@shanghaitech.edu.cn
dataset submitter
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