PXD035829
PXD035829 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Phosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming |
| Description | To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBUMIN+ hepatocytes (CLiP-Hep) cells. To systematically interrogate the early regulatory events of hepatic reprogramming, we profiled the Phosphoproteome and proteome in human dermal fibroblasts (HDFs) at 2.25 days (FHH-2.25d) and 5 days (FHH-5d) after infection of lenti-virus encoding three liver-specific transcription factors, FOXA3, HNF1A and HNF4A (FHH). In this analysis, HDF infected with lenti-virus expressing GFP for 2.25 days (GFP) were used as control. |
| HostingRepository | iProX |
| AnnounceDate | 2022-08-05 |
| AnnouncementXML | Submission_2023-03-01_22:59:26.238.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yangyang Yuan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-05 09:31:02 | ID requested | |
| 1 | 2022-08-05 09:32:27 | announced | |
| ⏵ 2 | 2023-03-01 22:59:27 | announced | 2023-03-02: Update publication information. |
Publication List
| Yuan Y, Wang C, Zhuang X, Lin S, Luo M, Deng W, Zhou J, Liu L, Mao L, Peng W, Chen J, Wang Q, Shu Y, Xue Y, Huang P, PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest. Nat Commun, 13(1):5237(2022) [pubmed] |
Keyword List
| submitter keyword: Phosphoproteome, proteome, hepatocyte maturation, hepatic reprogramming, TMT |
Contact List
| Yu Xue | |
|---|---|
| contact affiliation | Huazhong University of Science and Technology, Wuhan, China |
| contact email | xueyu@hust.edu.cn |
| lab head | |
| Yangyang Yuan | |
| contact affiliation | ShanghaiTech University, Shanghai, China |
| contact email | yuanyy@shanghaitech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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