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PXD035693

PXD035693 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA proteomic view of WT and △ydiV(stm1344) Salmonella Typhimurium in simulated host environment medium
DescriptionThe flagellum provides essential motility in the pathogenic process of Salmonella host invasion. However, flagellin is strongly antigenic and can be recognized by TLR5, resulting in activation of the host immune system to clear the invading pathogen. The presence of flagella also disrupts the integrity of the bacterial cytosol, making it more vulnerable to external adversities. Salmonella must rapidly shut down the flagella synthesis system after entering the host cell to evade the host immune system and resist damage from external adverse factors. Our studies showed YdiV(STM1344) play a key role in regulating the transcription of flagella-related genes during Salmonella invasion. After the ydiV(stm1344) gene was knocked out, the pathogenicity of Salmonella was significantly reduced. Here, we performed a TMT-based comparative quantitative proteomics analysis to reveal the proteomic differences between the WT and △ydiV(stm1344) in simulated host environment medium.
HostingRepositoryPRIDE
AnnounceDate2022-10-12
AnnouncementXMLSubmission_2022-10-12_09:42:27.428.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaihongJia
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-01 09:30:46ID requested
12022-10-12 09:42:27announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: differential protein expression
simulated host environment medium
WT and △ydiV
Contact List
Bingqing Li, Yingying Yue, HaihongJia
contact affiliationKey Laboratory of Rare and Uncommon Diseases, Department of Microbiology, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences
contact emailbingqingsdu@163.com
lab head
HaihongJia
contact affiliationKey Laboratory of Rare and Uncommon Diseases, Department of Microbiology, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences
contact emailjia11112222@126.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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