PXD035693 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic view of WT and △ydiV(stm1344) Salmonella Typhimurium in simulated host environment medium |
Description | The flagellum provides essential motility in the pathogenic process of Salmonella host invasion. However, flagellin is strongly antigenic and can be recognized by TLR5, resulting in activation of the host immune system to clear the invading pathogen. The presence of flagella also disrupts the integrity of the bacterial cytosol, making it more vulnerable to external adversities. Salmonella must rapidly shut down the flagella synthesis system after entering the host cell to evade the host immune system and resist damage from external adverse factors. Our studies showed YdiV(STM1344) play a key role in regulating the transcription of flagella-related genes during Salmonella invasion. After the ydiV(stm1344) gene was knocked out, the pathogenicity of Salmonella was significantly reduced. Here, we performed a TMT-based comparative quantitative proteomics analysis to reveal the proteomic differences between the WT and △ydiV(stm1344) in simulated host environment medium. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-12 |
AnnouncementXML | Submission_2022-10-12_09:42:27.428.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | HaihongJia |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-01 09:30:46 | ID requested | |
⏵ 1 | 2022-10-12 09:42:27 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: differential protein expression |
simulated host environment medium |
WT and △ydiV |
Contact List
Bingqing Li, Yingying Yue, HaihongJia |
contact affiliation | Key Laboratory of Rare and Uncommon Diseases, Department of Microbiology, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences |
contact email | bingqingsdu@163.com |
lab head | |
HaihongJia |
contact affiliation | Key Laboratory of Rare and Uncommon Diseases, Department of Microbiology, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences |
contact email | jia11112222@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035693
- Label: PRIDE project
- Name: A proteomic view of WT and △ydiV(stm1344) Salmonella Typhimurium in simulated host environment medium