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PXD035673-2

PXD035673 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExosome proteomics reveals the deregulation of coagulation, complement and lipid metabolism proteins in gestational diabetes mellitus
DescriptionExosomes are the smallest extracellular vesicles which are released during pregnancy by the placenta, umbilical cord, amniotic fluid and various cell membranes in the extracellular space. The content of exosomes during pregnancy is strongly related to various conditions such as gestational diabetes mellitus (GDM). Although it is well-known that GDM is characterized by different levels of chronic low-grade inflammation, complement system dysregulation, vascular dysfunction and platelet activation, there is little data characterizing the serum exosomal protein cargo of GDM patients and their associations to these processes. The aim of this study was to analyze the serum exosomal proteome of GDM patients, with focus on the platelet activation and the complement proteins and their relationship to serum biochemical parameters and other protein markers of lipid metabolism and prothrombotic factors.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:57:47.298.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFelicia Antohe
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-01 02:42:22ID requested
12022-09-21 23:25:09announced
22023-11-14 08:57:47announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, lipid metabolism, mass spectrometry, Prothrombotic factors, Complement system,gestational diabetes mellitus, Platelet activation
Contact List
Felicia Antohe
contact affiliationInstitute of Cellular Biology and Pathology
contact emailfelicia.antohe@icbp.ro
lab head
Felicia Antohe
contact affiliationInstitute of Cellular Biology and Pathology "N. Simionescu"
contact emailfelicia.antohe@icbp.ro
dataset submitter
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Dataset FTP location
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PRIDE project URI
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