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PXD035587-1

PXD035587 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUnique Ligand and Kinase-Independent Roles of the Insulin Receptor in Regulation of Cell Cycle, Senescence and Apoptosis
DescriptionInsulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic and mitogenic actions. Here, using receptors with either short or long deletion of the β-subunit or mutation of the kinase active site (K1030R, we uncover a second novel IR signaling pathway that is intracellular domain dependent, but ligand and tyrosine kinase-independent (LYK-I). These LYK-I actions of the IR are linked to changes in phosphorylation of a network of proteins involved in the regulation of extracellular matrix organization, cell cycle, ATM signaling and cellular senescence; and result in upregulation of expression of multiple extracellular matrix-related genes and proteins, down-regulation of immune/interferon-related genes and proteins, and increased sensitivity to apoptosis. Thus, in addition to classical ligand and tyrosine kinase-dependent (LYK-D) signaling, the IR regulates a second, novel ligand and tyrosine kinase-independent (LYK-I) pathway which regulates the cellular machinery involved in senescence, matrix interaction and response to extrinsic challenges.
HostingRepositoryPRIDE
AnnounceDate2023-01-02
AnnouncementXMLSubmission_2023-01-02_08:25:26.471.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAshokkumarJayavelu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-25 11:27:07ID requested
12023-01-02 08:25:26announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human,Kinase, Diabetes, Insulin Receptor,Insulin
Contact List
Dr.Ashok KumarJayavelu
contact affiliationProteomics and Cancer Cell Signaling, Deutsches Krebsforschungszentrum,Heidelberg
contact emailak.jayavelu@dkfz-heidelberg.de
lab head
AshokkumarJayavelu
contact affiliationDept Proteomics and Signal Transduction, MaxPlanck Institute of Biochemistry
contact emailjayavelu@biochem.mpg.de
dataset submitter
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Dataset FTP location
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