PXD035552-1

PXD035552 is an original dataset announced via ProteomeXchange.

Title	Mouse muscle spindle proteomics
Description	The proprioceptive system is essential for the control of coordinated movement, posture and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle. We then associated differentially expressed genes with the various tissues composing the spindle using bioinformatic analysis. Immunostaining verified these predictions, thus establishing new markers for the different spindle tissues. Utilizing these markers, we identified the differentiation stages the spindle capsule cells undergo during development. Together, these findings provide comprehensive molecular characterization of the intact spindle as well as new tools to study its development and function in health and disease.
HostingRepository	PRIDE
AnnounceDate	2023-02-17
AnnouncementXML	Submission_2023-02-17_02:01:28.966.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AlonSavidor
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-24 05:24:33	ID requested
⏵ 1	2023-02-17 02:01:29	announced
2	2023-11-14 08:03:32	announced	2023-11-14: Updated project metadata.

Bornstein B, Heinemann-Yerushalmi L, Krief S, Adler R, Dassa B, Leshkowitz D, Kim M, Bewick G, Banks RW, Zelzer E, Molecular characterization of the intact mouse muscle spindle using a multi-omics approach. Elife, 12():(2023) [pubmed]

submitter keyword: proteomics, nerve,Spindle, LFQ, mouse, DDA, muscle

Prof. ElazarZelzer
contact affiliation	Department of Molecular Genetics Faculty of Biochemistry Weizmann Institute of Science Rehovot 7610001 Israel
contact email	eli.zelzer@weizmann.ac.il
lab head
AlonSavidor
contact affiliation	The Weizmann Institute of Science
contact email	alon.savidor@weizmann.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD035552

PRIDE project URI

• PRIDE
  1. PXD035552
     1. Label: PRIDE project
     2. Name: Mouse muscle spindle proteomics