PXD035552 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mouse muscle spindle proteomics |
Description | The proprioceptive system is essential for the control of coordinated movement, posture and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle. We then associated differentially expressed genes with the various tissues composing the spindle using bioinformatic analysis. Immunostaining verified these predictions, thus establishing new markers for the different spindle tissues. Utilizing these markers, we identified the differentiation stages the spindle capsule cells undergo during development. Together, these findings provide comprehensive molecular characterization of the intact spindle as well as new tools to study its development and function in health and disease. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:03:32.076.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alon Savidor |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-24 05:24:33 | ID requested | |
1 | 2023-02-17 02:01:29 | announced | |
⏵ 2 | 2023-11-14 08:03:32 | announced | 2023-11-14: Updated project metadata. |
Publication List
Bornstein B, Heinemann-Yerushalmi L, Krief S, Adler R, Dassa B, Leshkowitz D, Kim M, Bewick G, Banks RW, Zelzer E, Molecular characterization of the intact mouse muscle spindle using a multi-omics approach. Elife, 12():(2023) [pubmed] |
Keyword List
submitter keyword: proteomics, nerve,Spindle, LFQ, mouse, DDA, muscle |
Contact List
Prof. Elazar Zelzer |
contact affiliation | Department of Molecular Genetics Faculty of Biochemistry Weizmann Institute of Science Rehovot 7610001 Israel |
contact email | eli.zelzer@weizmann.ac.il |
lab head | |
Alon Savidor |
contact affiliation | The Weizmann Institute of Science |
contact email | alon.savidor@weizmann.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD035552 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035552
- Label: PRIDE project
- Name: Mouse muscle spindle proteomics