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PXD035477-1

PXD035477 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways
DescriptionChaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding and intracellular trafficking. Some Mycoplasmas are associated with cancers, and we demonstrated that infection with a strain of Mycoplasma fermentans isolated in our lab promoted lymphoma in a mouse model. Its DnaK is expressed intracellularly in infected cells, it interacts with key proteins to hamper essential pathways related to DNA repair and p53 functions and uninfected cells can take-up extracellular DnaK.
HostingRepositoryPRIDE
AnnounceDate2022-10-12
AnnouncementXMLSubmission_2022-10-12_09:48:35.917.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNicholasSherman
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-21 03:39:55ID requested
12022-10-12 09:48:36announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, cellular pathways, Chaperone protein, DnaK protein,Mycoplasma fermentans
Contact List
DavideZella
contact affiliationInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA
contact emailDZella@ihv.umaryland.edu
lab head
NicholasSherman
contact affiliationUniversity of Virginia
contact emailnes3f@virginia.edu
dataset submitter
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Dataset FTP location
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