PXD035374

PXD035374 is an original dataset announced via ProteomeXchange.

Title	Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system
Description	Combustible cigarettes produce many toxic substances that have been linked to diseases such as lung cancer and chronic obstructive pulmonary disease (COPD). Electronic cigarettes (e-cigarettes) can be used as an alternative to cigarettes for smokers who are unable or unwilling to quit. However, the effects and mechanisms of e-cigarette aerosol (ECA) on respiratory function have not been fully elucidated, and in vivo studies of its safety are limited compared to cigarette smoke (CS). In this article, we chose nicotine levels as the dose reference and selected C57BL/6 mice for a 10-week subchronic inhalation toxicity study. A comprehensive set of toxicological endpoints was used to study the effects of exposure. Thus, additional evidence is provided for the relative safety of e-cigarettes.
HostingRepository	iProX
AnnounceDate	2022-07-14
AnnouncementXML	Submission_2022-12-24_20:54:13.440.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wanchun Yang
SpeciesList	scientific name: Mus ; NCBI TaxID: 10088;
ModificationList	No PTMs are included in the dataset
Instrument	Thermo Scientific instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-17 20:08:11	ID requested
1	2022-07-17 20:08:29	announced
⏵ 2	2022-12-24 20:54:14	announced	2022-12-25: Update publication information.

Yang W, Yang X, Jiang L, Song H, Huang G, Duan K, Jiang X, Li M, Liu P, Chen J, Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system. Arch Toxicol, 96(12):3331-3347(2022) [pubmed]

submitter keyword: Electronic cigarettes, Combustible cigarettes, Proteomics, Respiratory system, Inhalation, In vivo

Jianwen Chen
contact affiliation	Sun Yat-sen University
contact email	chenjwen@mail.sysu.edu.cn
lab head
Wanchun Yang
contact affiliation	Sun Yat-sen University
contact email	yangwch8@mail2.sysu.edu.cn
dataset submitter

iProX dataset URI