PXD035187-1

PXD035187 is an original dataset announced via ProteomeXchange.

Title	CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway
Description	SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative proteomics data and pulldown assay, we identified cyclin-dependent kinase 9 (CDK9) as a novel therapeutic target in regeneration therapy.
HostingRepository	iProX
AnnounceDate	2022-07-09
AnnouncementXML	Submission_2022-09-27_01:02:36.377.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiateng Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-08 23:04:28	ID requested
⏵ 1	2022-09-27 01:02:37	announced

Sun J, Yang T, Wei T, Zhou L, Shan T, Chen J, Gu L, Chen B, Liu L, Jiang Q, Du C, Ma Y, Wang H, Chen F, Guo X, Ji Y, Wang L, -catenin pathway. Front Cardiovasc Med, 9():970745(2022) [pubmed]

submitter keyword: Myocardial infarction, Myocardial regeneration, SGK3, CDK9

Liansheng Wang
contact affiliation	the First Affiliated Hospital of Nanjing Medical University
contact email	drlswang@njmu.edu.cn
lab head
Jiateng Sun
contact affiliation	the First Affiliated Hospital of Nanjing Medical University
contact email	sunjiateng@126.com
dataset submitter

iProX dataset URI