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PXD035082-2

PXD035082 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of the secretome of a esxaA mutant Mycobacterium tuberculosis strain
DescriptionExtracellular Mycobacterium tuberculosis (Mtb) aggregates can evade phagocytosis and intracellular host-cell defenses by inducing macrophage killing. We showed that Mtb aggregates require a functional ESX-1 type VII secretion system to induce cell death upon contact with macrophages. We used quantitative proteomics to compare the secretome of a esxA mutant strain with the wild type reference to identify secreted bacteria factors involved in macrophage death induction.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:57:17.117.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChiara Toniolo
SpeciesList scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium tuberculosis; NCBI TaxID: 1773;
ModificationListphosphorylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-04 15:00:59ID requested
12023-03-16 02:59:12announced
22023-11-14 08:57:17announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Mycobacterium tuberculosis, esxA, secretome
Contact List
john McKinney
contact affiliationSchool of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL)
contact emailjohn.mckinney@epfl.ch
lab head
Chiara Toniolo
contact affiliationEcole Polotechnique Federale de Lausanne (EPFL), SV, GHI, UPKIN
contact emailchiara.toniolo87@gmail.com
dataset submitter
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Dataset FTP location
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