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PXD034899-1

PXD034899 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAcetylation of p62 regulates base excision repair through interaction with APE1
Descriptionp62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxidizing agents. In response to alkylative and oxidative damage, p62 is accumulated in the nucleus,acetylated by hMOF, deacetylated by SIRT7, and acetylated p62 is recruited to chromatin. The chromatin-enriched p62 directly interacts with APE1, a key enzyme of the BER pathway, and promotes its endonuclease activity, which facilitates BER and cell survival. Collectively, our findings demonstrate that p62 is a regulator of BER, and provide further rationale for targeting p62 as a cancer therapeutic strategy.
HostingRepositoryPRIDE
AnnounceDate2022-07-19
AnnouncementXMLSubmission_2022-07-18_19:17:36.110.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMeiting Li
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-26 07:30:44ID requested
12022-07-18 19:17:36announced
22023-11-14 08:56:09announced2023-11-14: Updated project metadata.
Publication List
10.1016/J.CELREP.2022.111116;
Keyword List
submitter keyword: Base excision repair, p62, Acetylation, hMOF, SIRT7, APE1
Contact List
Haiying Wang
contact affiliationBeijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
contact emailwendy@bjmu.edu.cn
lab head
Meiting Li
contact affiliationPeking University Health Science Center
contact emailLimeiting401@163.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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