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PXD034840-2

PXD034840 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients
DescriptionInnovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represents an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis promote neuroprotection and remyelination by releasing molecules sustaining trophic support and neural plasticity. We present the results of STEMS, a single dose escalation phase I clinical trial, evaluating the feasibility, safety, and tolerability of intrathecally transplanted human fetal NPCs (hfNPCs) in 12 PMS patients.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:01:07.587.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD034840
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAnnapaola Andolfo
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-06-22 14:16:46ID requested
12022-11-18 11:10:16announced
22023-11-14 09:01:08announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD034840;
Keyword List
submitter keyword: Progressive multiple sclerosis, cerebrospinal fluid, neural stem cells, transplantation, quantitative proteomics
Contact List
Gianvito Martino
contact affiliationNeuroimmunology Unit Institute of Experimental Neurology San Raffaele Scientific Institute Via Olgettina 60 Milan 20132, Italy
contact emailmartino.gianvito@hsr.it
lab head
Annapaola Andolfo
contact affiliationOspedale San Raffaele
contact emailandolfo.annapaola@hsr.it
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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