PXD034794

PXD034794 is an original dataset announced via ProteomeXchange.

Title	Ferritin-mediated iron detoxification mediates hypothermia survival in Caenorhabditis elegans and murine neurons.
Description	How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein related to mammalian ferritin heavy chain (FTH1). Moreover, we show that inducing expression of FTH1 also promotes cold survival of mammalian neurons, a cell type particularly sensitive to deterioration in hypothermia. Our findings in both animals and cells suggest that FTN-1/FTH1 facilitates cold survival by detoxifying ROS-generating iron species. We finally show that mimicking the effects of FTN-1/FTH1 with drugs protects neurons from cold-induced degeneration, opening a potential avenue to improved treatments of hypothermia.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:19:34.632.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD034794
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bernd Thiede
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-21 08:22:02	ID requested
1	2022-10-13 22:20:18	announced
⏵ 2	2023-11-14 08:19:35	announced	2023-11-14: Updated project metadata.

10.6019/PXD034794;

Pekec T, Lewandowski J, Komur AA, Soba, ń, ska D, Guo Y, Ś, wito, ń, ska-Kurkowska K, Ma, ł, ecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R, Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nat Commun, 13(1):4883(2022) [pubmed]

submitter keyword: ferritin heavy chain, ferrous iron, FoxO, ETS-4, neuroprotection, ferroxidase, DAF-16, FTH1, cold, FTN-1, PQM-1, ROS, antioxidant, hibernation, iron, Fe2+,Hypothermia

Rafal Ciosk
contact affiliation	University of Oslo, Department of Biosciences, Oslo, Norway
contact email	rafal.ciosk@ibv.uio.no
lab head
Bernd Thiede
contact affiliation	University of Oslo
contact email	bernd.thiede@ibv.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034794

PRIDE project URI

• PRIDE
  1. PXD034794
     1. Label: PRIDE project
     2. Name: Ferritin-mediated iron detoxification mediates hypothermia survival in Caenorhabditis elegans and murine neurons.