PXD034548-1
PXD034548 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | β-thalassemia plasma EVs proteomics |
Description | Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the biomarker potential of both specimens. We first described the pathophysiological characteristics of different subtypes. More significant immunity abnormalities and lipid metabolism was separately observed in patients with TI and TM, which was consistent with the results of paired plasma proteomics. A diagnostic model consisting of six proteins with subtyping potential was proposed. Of note, superior performance of plasma EVs on patient subgroup differentiating was shown than plasma, demonstrating the potential of secreted EVs for diagnosis of β-thalassemia patients. |
HostingRepository | iProX |
AnnounceDate | 2022-06-15 |
AnnouncementXML | Submission_2023-01-09_00:37:25.800.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Na Li |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | TMT6plex reporter fragment; iodoacetamide derivatized residue; methionine oxidation with neutral loss of 64 Da |
Instrument | Orbitrap Eclipse; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-06-15 18:41:54 | ID requested | |
⏵ 1 | 2023-01-09 00:37:26 | announced | |
2 | 2023-03-01 19:01:16 | announced | 2023-03-02: Update publication information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: β-thalassemia, extracellular vesicles (EVs), proteomics, biomarker |
Contact List
Fuquan Yang | |
---|---|
contact affiliation | Institute of Biophysics, Chinese Academy of Sciences |
contact email | fqyang@ibp.ac.cn |
lab head | |
Na Li | |
contact affiliation | Institute of Biophysics, Chinese Academy of Sciences |
contact email | lina@ibp.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |