PXD034548

PXD034548 is an original dataset announced via ProteomeXchange.

Title	β-thalassemia plasma EVs proteomics
Description	Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the biomarker potential of both specimens. We first described the pathophysiological characteristics of different subtypes. More significant immunity abnormalities and lipid metabolism was separately observed in patients with TI and TM, which was consistent with the results of paired plasma proteomics. A diagnostic model consisting of six proteins with subtyping potential was proposed. Of note, superior performance of plasma EVs on patient subgroup differentiating was shown than plasma, demonstrating the potential of secreted EVs for diagnosis of β-thalassemia patients.
HostingRepository	iProX
AnnounceDate	2022-06-15
AnnouncementXML	Submission_2023-03-01_19:01:15.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Na Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment; iodoacetamide derivatized residue; methionine oxidation with neutral loss of 64 Da
Instrument	Orbitrap Eclipse; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-15 18:41:54	ID requested
1	2023-01-09 00:37:26	announced
⏵ 2	2023-03-01 19:01:16	announced	2023-03-02: Update publication information.

Li N, Wu B, Wang J, Yan Y, An P, Li Y, Liu Y, Hou Y, Qing X, Niu L, Ding X, Xie Z, Zhang M, Guo X, Chen X, Cai T, Luo J, Wang F, Yang F, -thalassemia subtypes. iScience, 26(2):106048(2023) [pubmed]

submitter keyword: β-thalassemia, extracellular vesicles (EVs), proteomics, biomarker

Fuquan Yang
contact affiliation	Institute of Biophysics, Chinese Academy of Sciences
contact email	fqyang@ibp.ac.cn
lab head
Na Li
contact affiliation	Institute of Biophysics, Chinese Academy of Sciences
contact email	lina@ibp.ac.cn
dataset submitter

iProX dataset URI