PXD034150-2
PXD034150 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic profiling reveals the molecular control of oocyte maturation |
Description | Meiotic maturation is an intricate and precisely regulated process orchestrated 32 by various pathways and numerous proteins. However, little is known about the 33 proteome landscape during oocytes maturation. Here, we obtained the temporal 34 proteomic profiles of mouse oocytes during in vivo maturation. We successfully 35 quantified 4,694 proteins from 4,500 oocytes in three key stages (GV, GVBD, and 36 MII). In particular, we discovered the novel proteomic features during oocyte 37 maturation, such as the active Skp1–Cullin–Fbox pathway and an increase in 38 mRNA-decay-related proteins. Using functional approaches, we further identified the 39 key factors controlling the histone acetylation state in oocytes and the vital proteins 40 modulating meiotic cell cycle. Taken together, our data serve as a broad resource on 41 the dynamics occurring in oocyte proteome and provide important knowledge to 42 better understand the molecular mechanisms during germ cell development. |
HostingRepository | iProX |
AnnounceDate | 2022-05-26 |
AnnouncementXML | Submission_2023-01-28_19:50:33.081.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Haotian Zhang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-05-26 19:21:09 | ID requested | |
1 | 2022-05-26 19:21:22 | announced | |
⏵ 2 | 2023-01-28 19:50:33 | announced | 2023-01-29: Update publication information. |
Publication List
Sun H, Sun G, Zhang H, An H, Guo Y, Ge J, Han L, Zhu S, Tang S, Li C, Xu C, Guo X, Wang Q, Proteomic Profiling Reveals the Molecular Control of Oocyte Maturation. Mol Cell Proteomics, 22(1):100481(2023) [pubmed] |
Keyword List
submitter keyword: oocyte, proteome, epigenetics, mRNA decay, ubiquitination |
Contact List
Xuejiang Guo | |
---|---|
contact affiliation | Nanjing Medical University |
contact email | guo_xuejiang@njmu.edu.cn |
lab head | |
Haotian Zhang | |
contact affiliation | Nanjing Medical University |
contact email | zhtclearlove@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |