PXD034150

PXD034150 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling reveals the molecular control of oocyte maturation
Description	Meiotic maturation is an intricate and precisely regulated process orchestrated 32 by various pathways and numerous proteins. However, little is known about the 33 proteome landscape during oocytes maturation. Here, we obtained the temporal 34 proteomic profiles of mouse oocytes during in vivo maturation. We successfully 35 quantified 4,694 proteins from 4,500 oocytes in three key stages (GV, GVBD, and 36 MII). In particular, we discovered the novel proteomic features during oocyte 37 maturation, such as the active Skp1–Cullin–Fbox pathway and an increase in 38 mRNA-decay-related proteins. Using functional approaches, we further identified the 39 key factors controlling the histone acetylation state in oocytes and the vital proteins 40 modulating meiotic cell cycle. Taken together, our data serve as a broad resource on 41 the dynamics occurring in oocyte proteome and provide important knowledge to 42 better understand the molecular mechanisms during germ cell development.
HostingRepository	iProX
AnnounceDate	2022-05-26
AnnouncementXML	Submission_2023-01-28_19:50:33.081.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haotian Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-26 19:21:09	ID requested
1	2022-05-26 19:21:22	announced
⏵ 2	2023-01-28 19:50:33	announced	2023-01-29: Update publication information.

Sun H, Sun G, Zhang H, An H, Guo Y, Ge J, Han L, Zhu S, Tang S, Li C, Xu C, Guo X, Wang Q, Proteomic Profiling Reveals the Molecular Control of Oocyte Maturation. Mol Cell Proteomics, 22(1):100481(2023) [pubmed]

submitter keyword: oocyte, proteome, epigenetics, mRNA decay, ubiquitination

Xuejiang Guo
contact affiliation	Nanjing Medical University
contact email	guo_xuejiang@njmu.edu.cn
lab head
Haotian Zhang
contact affiliation	Nanjing Medical University
contact email	zhtclearlove@163.com
dataset submitter

iProX dataset URI