PXD034080 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomics of primary human FLT3-ITD+ AML cells treated with gilteritinib |
Description | Primary human AML cells (newly diagnosed, prior to treatment initation) were obtained from donor after consent and AML blasts were isolated by standard Ficoll centrifugation. AML blasts were treated with FLT3 inhibitor gilteritinib (or DMSO vehicle control) at 10 nM concentration for 6 h, followed by harvest for LC/MS. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-25 |
AnnouncementXML | Submission_2022-08-25_03:26:19.658.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sebastian Koschade |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-25 02:32:36 | ID requested | |
⏵ 1 | 2022-08-25 03:26:20 | announced | |
Publication List
Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Th, ö, lken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, M, ü, nch C, Brandts CH, Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia, 36(10):2396-2407(2022) [pubmed] |
Keyword List
submitter keyword: AML, FLT3, gilteritinib |
Contact List
Christian Münch |
contact affiliation | Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany |
contact email | ch.muench@em.uni-frankfurt.de |
lab head | |
Sebastian Koschade |
contact affiliation | Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany & Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany |
contact email | koschade@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD034080 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034080
- Label: PRIDE project
- Name: Phosphoproteomics of primary human FLT3-ITD+ AML cells treated with gilteritinib