PXD033998 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mice bone marrow-derived dendritic cells (BMDC) infected by Listeria: extracellular vesicles (EVs) proteome and PTMs |
Description | In this study, we aimed to determine the role of EVs derived from Lm-infected DCs in the innate response, and the potential role of HDAC6 in DEV loading under these conditions. Our results show that Lm infection induced an elevated production of DEVs. Lm infection also altered protein sorting. Interestingly, HDAC6 deletion altered DEV protein sorting, although it did not affect acetylation of DEV-loaded proteins. However, protein ubiquitination was severely altered. Here, we show that the protein content of dendritic cells (DCs) and their secreted EVs (DEVs) vary dramatically during Lm infection. The proteomic profiles of DCs and DEV differ depending on whether HDAC6 is expressed or not. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-30 |
AnnouncementXML | Submission_2022-08-30_02:42:14.807.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Inmaculada Jorge |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | ubiquitinylated lysine; acetylated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-19 03:34:16 | ID requested | |
⏵ 1 | 2022-08-30 02:42:15 | announced | |
Publication List
Keyword List
submitter keyword: Extracellular vesicles from dendritic cells, HDAC6-KO, multiplexed quantitative proteomics, ubiquitinilation, acetylation |
Contact List
Jesús María Vázquez Cobos |
contact affiliation | Centron Nacional de Investigaciones Cardiovasculares, CNIC (Masdrid, Spain). |
contact email | jvazquez@cnic.es |
lab head | |
Inmaculada Jorge |
contact affiliation | Vascular Biology and Inflammation |
contact email | ijorge@cnic.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033998
- Label: PRIDE project
- Name: Mice bone marrow-derived dendritic cells (BMDC) infected by Listeria: extracellular vesicles (EVs) proteome and PTMs