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PXD033653-2

PXD033653 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic changes in the hypothalamus after treatment with GLP-1RA, Tesaglitazar, or GLP-1RA/Tesaglitazar (GLP-1RA mediated Tesaglitazar delivery)
DescriptionThe peroxisome proliferator-activated receptors alpha and gamma (PPARš¯›¼/š¯›¾) play important roles in the regulation of energy, lipid and glucose metabolism. Drugs targeting these proteins such as Fibrates and TZDs have both shown beneficial cardiovascular effects in clinical trials, which together with their complementary action on glucose and lipid metabolism spurred the development of PPARš¯›¼/š¯›¾ dual-agonists (Glitazars) for the treatment of type-2 diabetes (T2D) and dyslipidemia. While effectively improving glucose and lipid metabolism in clinical trials, the development of many Glitazars was terminated due to unfavorable effects on the cardiovascular and/or renal system. Here we evaluate a single molecule conjugate of the PPARš¯›¼/š¯›¾ dual-agonist Tesaglitazar covalently attached to the incretin hormone glucagon-like peptide-1 receptor agonist (GLP-1RA). We hypothesized that GLP-1-mediated delivery of Tesaglitazar as well as synergism between the two agents would lead to overal beneficial effects and decrease the TZD risk profile.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:26:58.078.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNatalie Krahmer
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-04 15:30:05ID requested
12022-10-07 04:13:41announced
22023-11-14 08:26:58announced2023-11-14: Updated project metadata.
Publication List
Quarta C, Stemmer K, Novikoff A, Yang B, Klingelhuber F, Harger A, Bakhti M, Bastidas-Ponce A, Baug, Ć© E, Campbell JE, Capozzi M, Clemmensen C, Collden G, Cota P, Douros J, Drucker DJ, DuBois B, Feuchtinger A, Garcia-Caceres C, Grandl G, Hennuyer N, Herzig S, Hofmann SM, Knerr PJ, Kulaj K, Lalloyer F, Lickert H, Liskiewicz A, Liskiewicz D, Maity G, Perez-Tilve D, Prakash S, Sanchez-Garrido MA, Zhang Q, Staels B, Krahmer N, DiMarchi RD, Tsch, ƶ, p MH, Finan B, M, Ć¼, ller TD, GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nat Metab, 4(8):1071-1083(2022) [pubmed]
Keyword List
submitter keyword: Tesaglitazar, GLP-1RA, GLP-1, Mouse, Hypothalamus, targeted delivery
Contact List
Natalie Krahmer
contact affiliationInstitute for Diabetes and Obesity, Helmholtz Zentrum MĆ¼nchen, 85764 Neuherberg, Germany German Center for Diabetes Research, Neuherberg, Germany
contact emailnatalie.krahmer@helmholtz-muenchen.de
lab head
Natalie Krahmer
contact affiliationHelmholtz Center Munich
contact emailnatalie.krahmer@helmholtz-muenchen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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