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PXD033351-1

PXD033351 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePan-cancer tumor-specific antigens and membrane targets from transposable elements
DescriptionCryptic promoters within transposable elements (TEs) are transcriptionally reactivated in tumors to create novel TE-gene chimeric transcripts, which can produce immunogenic antigens. We performed the most comprehensive screen to date for these TE exaptation events in 33 TCGA tumor types, 675 cancer cell lines, and 11,686 GTEx adult tissue transcriptomes and identified 1,068 TE-exapted candidates with the potential to generate shared tumor-specific TE-chimeric antigens (TS-TEAs). Resultant whole lysate and HLA-pulldown mass spectrometry data confirmed that TS-TEAs are presented on cancer cell surfaces. In addition, we highlight the tumor-specific membrane proteins transcribed from TE promoters that can expose novel epitopes on the extracellular surface of cancer cells. Here, we showcase the high pan-cancer prevalence of TS-TEAs and atypical membrane proteins that can be therapeutically exploited through immunotherapy approaches.
HostingRepositoryPRIDE
AnnounceDate2023-01-21
AnnouncementXMLSubmission_2023-01-20_21:10:02.623.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJu HeonMaeng
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-21 06:57:16ID requested
12023-01-20 21:10:03announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, transposable element, antigen, Cancer, MHC pulldown, LC-MS/MS
Contact List
TingWang
contact affiliationDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
contact emailtwang@genetics.wustl.edu
lab head
Ju HeonMaeng
contact affiliationWashington University in St. Louis
contact emailj.maeng@wustl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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