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PXD033249-1

PXD033249 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSilent recognition by Toll-like receptor 5 of flagellins from human gut commensal bacteria
DescriptionFlagellins from commensal bacteria can be weak Toll-like receptor (TLR)5 agonists despite high affinity binding to TLR5, ligands we termed “silent flagellins”. To determine if silent flagellins are detectable in the human gut, endogenous flagellins produced by the microbiota were isolated from stool obtained from a healthy adult female donor. TLR5 was used as bait to enrich for silent flagellins and TLR5-bound flagellins were identified by searching peptides against a custom flagellin database built from metagenome sequences.
HostingRepositoryPRIDE
AnnounceDate2022-10-12
AnnouncementXMLSubmission_2022-10-12_08:54:31.770.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIrinaDroste-Borel
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-04-14 05:42:46ID requested
12022-10-12 08:54:32announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Silent recognition, Commensal-derived flagellins,Toll-like receptor 5, Silent flagellins
Contact List
Ruth E.Ley
contact affiliationDepartment of Microbiome Science, Max Planck Institute for Biology, Tübingen 72076, Germany. Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.
contact emailruth.ley@tuebingen.mpg.de
lab head
IrinaDroste-Borel
contact affiliationProf. Boris Macek Proteome Center Tuebingen University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen
contact emailirina.droste-borel@uni-tuebingen.de
dataset submitter
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Dataset FTP location
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