PXD033249

PXD033249 is an original dataset announced via ProteomeXchange.

Title	Silent recognition by Toll-like receptor 5 of flagellins from human gut commensal bacteria
Description	Flagellins from commensal bacteria can be weak Toll-like receptor (TLR)5 agonists despite high affinity binding to TLR5, ligands we termed “silent flagellins”. To determine if silent flagellins are detectable in the human gut, endogenous flagellins produced by the microbiota were isolated from stool obtained from a healthy adult female donor. TLR5 was used as bait to enrich for silent flagellins and TLR5-bound flagellins were identified by searching peptides against a custom flagellin database built from metagenome sequences.
HostingRepository	PRIDE
AnnounceDate	2022-10-12
AnnouncementXML	Submission_2022-10-12_08:54:31.770.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	IrinaDroste-Borel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-14 05:42:46	ID requested
⏵ 1	2022-10-12 08:54:32	announced

Dataset with its publication pending

submitter keyword: Silent recognition, Commensal-derived flagellins,Toll-like receptor 5, Silent flagellins

Ruth E.Ley
contact affiliation	Department of Microbiome Science, Max Planck Institute for Biology, Tübingen 72076, Germany. Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany.
contact email	ruth.ley@tuebingen.mpg.de
lab head
IrinaDroste-Borel
contact affiliation	Prof. Boris Macek Proteome Center Tuebingen University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen
contact email	irina.droste-borel@uni-tuebingen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD033249

PRIDE project URI

• PRIDE
  1. PXD033249
     1. Label: PRIDE project
     2. Name: Silent recognition by Toll-like receptor 5 of flagellins from human gut commensal bacteria