PXD033221 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Combinatorial screening of biological degrader modules to destroy intractable proteins – nonkinetic data |
Description | Abstract – nonkinetic data Targeted protein degradation is a potent strategy against intracellular proteins impervious to traditional drugs. We describe a platform reliant on high-throughput cloning and mRNA-based delivery to quickly screen 100s-1000s modular biological degraders which we challenge against the intractable and high-turnover c-Myc oncoprotein. We uncover critical principles to drive the discovery of degraders against any target, capable of operating without prior cell line engineering, with direct applications in research and potentially therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:31:13.726.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | SonjaHess |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-14 04:14:40 | ID requested | |
⏵ 1 | 2023-11-14 07:31:14 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: trim21, nonkinetic data, DIA-MS,timsTOF, spectronaut, Protac |
Contact List
SonjaHess |
contact affiliation | Senior Director, Dynamic Omics, CGR, One Medimmune Way Gaithersburg, MD 20878 |
contact email | Sonja.Hess@astrazeneca.com |
lab head | |
SonjaHess |
contact affiliation | Dynamic Omics, CGR, Discovery Sciences, AstraZeneca |
contact email | sonja.hess@astrazeneca.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD033221
- Label: PRIDE project
- Name: Combinatorial screening of biological degrader modules to destroy intractable proteins – nonkinetic data