PXD033040 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes |
Description | The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium trafficking and bioenergetics. Previous studies suggest that disturbances in calcium trafficking and dysregulation of reactive oxygen species in the ER and mitochondria may contribute to the pathogenesis of diabetic retinopathy (DR). However, few studies have examined the impact of diabetes on the retinal MAM proteome profile. In the present study, we used Long Evans rats with streptozotocin-induced long-term Type 1 diabetes to identify key pathways and proteins in the retinal MAM that are potentially implicated in the pathogenesis of DR. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:26:46.979.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD033040 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Shichen Shen |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-07 02:45:31 | ID requested | |
1 | 2022-10-14 20:00:35 | announced | |
⏵ 2 | 2023-11-14 08:26:47 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD033040; |
Wang JJ, Park KS, Dhimal N, Shen S, Tang X, Qu J, Zhang SX, Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes. Cells, 11(18):(2022) [pubmed] |
Keyword List
submitter keyword: diabetic retinopathy |
Type 1 diabetes |
mitochondria-associated ER membrane |
proteomic |
retinal degeneration |
Contact List
Jun Qu |
contact affiliation | Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo |
contact email | junqu@buffalo.edu |
lab head | |
Shichen Shen |
contact affiliation | University at Buffalo |
contact email | shichens@buffalo.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD033040 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033040
- Label: PRIDE project
- Name: Proteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes