PXD033040

PXD033040 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes
Description	The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium trafficking and bioenergetics. Previous studies suggest that disturbances in calcium trafficking and dysregulation of reactive oxygen species in the ER and mitochondria may contribute to the pathogenesis of diabetic retinopathy (DR). However, few studies have examined the impact of diabetes on the retinal MAM proteome profile. In the present study, we used Long Evans rats with streptozotocin-induced long-term Type 1 diabetes to identify key pathways and proteins in the retinal MAM that are potentially implicated in the pathogenesis of DR.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:26:46.979.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD033040
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Shichen Shen
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-07 02:45:31	ID requested
1	2022-10-14 20:00:35	announced
⏵ 2	2023-11-14 08:26:47	announced	2023-11-14: Updated project metadata.

10.6019/PXD033040;

Wang JJ, Park KS, Dhimal N, Shen S, Tang X, Qu J, Zhang SX, Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes. Cells, 11(18):(2022) [pubmed]

submitter keyword: diabetic retinopathy

Type 1 diabetes

mitochondria-associated ER membrane

proteomic

retinal degeneration

Jun Qu
contact affiliation	Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo
contact email	junqu@buffalo.edu
lab head
Shichen Shen
contact affiliation	University at Buffalo
contact email	shichens@buffalo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD033040

PRIDE project URI

• PRIDE
  1. PXD033040
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes