PXD032785 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SWATH-MS based characterization for proteome profile data of chemicals |
Description | Profile data analysis is useful to reveal the mode of action of low molecular weight compounds. Although transcriptome data have been the main target of the profile data analysis, it is unknown whether omics data in different layers could deserve the profile data analysis. In the first place, what is not described as numerical data does not serve for analyses. Therefore, understanding the characteristics of omics data in different layers is crucial. In this study, we examined whether proteome data obtained by SWATH-MS (Sequential Window Acquisition of all Theoretical Mass Spectra) is useful to understand the mode of action of low molecular weight compounds. We demonstrated that proteome data obtained by SWATH-MS was useful for profile data analyses to the same extent as transcriptome data. Furthermore, we revealed a new mode of action of natural compound harmine as a result of profile data analysis using SWATH-MS data. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:55:56.486.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Risa Sato |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetic acid derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-24 13:27:16 | ID requested | |
1 | 2023-02-22 17:35:09 | announced | |
⏵ 2 | 2023-11-14 08:55:56 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: MCF7, OLSA, New mode of action, SWATH-MS |
Contact List
Yasuo Uchida |
contact affiliation | Graduate School of Pharmaceutical Sciences, Tohoku University |
contact email | yasuo.uchida.c8@tohoku.ac.jp |
lab head | |
Risa Sato |
contact affiliation | Tohoku University |
contact email | risa.sato.1022@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD032785 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032785
- Label: PRIDE project
- Name: SWATH-MS based characterization for proteome profile data of chemicals