PXD032766 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrated multi-omics analysis of adverse cardiac remodelling and metabolic inflexibility upon ErbB2 and ERR⍺ deficiency |
Description | Functional oncogenic links between ErbB2 and ERR⍺ in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERR⍺ also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Using integrated phosphoproteomic, transcriptomic and metabolic profiling, we uncovered molecular mechanisms associated with the adverse remodelling of cardiac functions in mice with combined attenuation of ErbB2 and ERR⍺ activity. Genetic disruption of both effectors results in profound effects on cardiomyocyte architecture, inflammatory response and metabolism, the latter leading to a decrease in fatty acyl-carnitine species further increasing the reliance on glucose as a metabolic fuel, a hallmark of failing hearts. Furthermore, integrated omics signatures of ERR⍺ loss-of-function and doxorubicin treatment exhibit reciprocal features of chemotherapeutic cardiotoxicity. These findings thus reveal potential cardiovascular risks in discrete combination therapies in the treatment of breast and other cancers. |
HostingRepository | PRIDE |
AnnounceDate | 2022-09-23 |
AnnouncementXML | Submission_2022-09-22_16:14:02.473.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Vincent Giguere |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-23 08:16:52 | ID requested | |
⏵ 1 | 2022-09-22 16:14:03 | announced | |
Publication List
Dufour CR, Xia H, B'chir W, Perry MC, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith HW, Muller WJ, Audet-Walsh E, Sergushichev AA, Emili A, Gigu, è, re V, deficiency. Commun Biol, 5(1):955(2022) [pubmed] |
Keyword List
submitter keyword: Mouse, heart, cardiac, phosphoproteome, estrogen related receptor, ErbB2, dilated cardiomyopathy |
Contact List
Vincent Giguere |
contact affiliation | McGill University - Rosalind & Morris Goodman Cancer Institute |
contact email | vincent.giguere@mcgill.ca |
lab head | |
Vincent Giguere |
contact affiliation | McGill University |
contact email | vincent.giguere@mcgill.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD032766 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032766
- Label: PRIDE project
- Name: Integrated multi-omics analysis of adverse cardiac remodelling and metabolic inflexibility upon ErbB2 and ERR⍺ deficiency