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PXD032766

PXD032766 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntegrated multi-omics analysis of adverse cardiac remodelling and metabolic inflexibility upon ErbB2 and ERR⍺ deficiency
DescriptionFunctional oncogenic links between ErbB2 and ERR⍺ in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERR⍺ also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Using integrated phosphoproteomic, transcriptomic and metabolic profiling, we uncovered molecular mechanisms associated with the adverse remodelling of cardiac functions in mice with combined attenuation of ErbB2 and ERR⍺ activity. Genetic disruption of both effectors results in profound effects on cardiomyocyte architecture, inflammatory response and metabolism, the latter leading to a decrease in fatty acyl-carnitine species further increasing the reliance on glucose as a metabolic fuel, a hallmark of failing hearts. Furthermore, integrated omics signatures of ERR⍺ loss-of-function and doxorubicin treatment exhibit reciprocal features of chemotherapeutic cardiotoxicity. These findings thus reveal potential cardiovascular risks in discrete combination therapies in the treatment of breast and other cancers.
HostingRepositoryPRIDE
AnnounceDate2022-09-23
AnnouncementXMLSubmission_2022-09-22_16:14:02.473.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVincent Giguere
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-23 08:16:52ID requested
12022-09-22 16:14:03announced
Publication List
Dufour CR, Xia H, B'chir W, Perry MC, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith HW, Muller WJ, Audet-Walsh E, Sergushichev AA, Emili A, Giguère V, Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency. Commun Biol, 5(1):955(2022) [pubmed]
Keyword List
submitter keyword: Mouse, heart, cardiac, phosphoproteome, estrogen related receptor, ErbB2, dilated cardiomyopathy
Contact List
Vincent Giguere
contact affiliationMcGill University - Rosalind & Morris Goodman Cancer Institute
contact emailvincent.giguere@mcgill.ca
lab head
Vincent Giguere
contact affiliationMcGill University
contact emailvincent.giguere@mcgill.ca
dataset submitter
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Dataset FTP location
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