PXD032359 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Circulating SOD2 is a Response Biomarker for Neoadjuvant Therapy in Breast Cancer |
Description | There is a great need of non-invasive tools that inform of an early molecular response to cancer therapeutic treatment. Here, we have tested the hypothesis that proteolytically resistant proteins could be candidate circulating tumor biomarkers for cancer therapy. Proteins resistant to proteolysis are drastically under-sampled by current proteomic workflows. These proteins could be reliable sensors for the response to therapy since they are likely to stay longer in circulation. We selected Manganese superoxide dismutase (SOD2), a mitochondrial redox enzyme, from a screening of proteolytic resistant proteins in breast cancer (BC). First, we confirmed the robustness of SOD2 and determined that its proteolytic resistance is mediated by its quaternary protein structure. We also proved that the release of SOD2 upon chemotherapy treatment correlates with cell death in BC cells. Then, after confirming that SOD2 is very stable in human serum, we sought to measure its circulating levels in a cohort of BC patients undergoing neoadjuvant therapy. The results showed that circulating levels of SOD2 increased when patients respond to the treatment according to the tumor shrinkage during neoadjuvant chemotherapy. Therefore, the measurement of SOD2 levels in plasma could improve the non-invasive monitoring of the therapeutic treatment in breast cancer patients. The identification of circulating biomarkers linked to the tumor cell death induced by treatment could be a useful for monitoring the action of the large number of cancer drugs currently used in the clinic. We envision that our approach could help uncover candidate tumor biomarkers to measure a tumor’s response to cancer therapy in real time by sampling the tumor throughout the course of treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:57:32.924.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Francesc Canals |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-17 04:22:31 | ID requested | |
1 | 2023-01-09 07:52:34 | announced | |
⏵ 2 | 2023-11-14 07:57:35 | announced | 2023-11-14: Updated project metadata. |
Publication List
Juliachs M, Pujals M, Bellio C, Meo-Evoli N, Duran JM, Zamora E, Par, é, s M, Su, ñ, ol A, M, é, ndez O, S, á, nchez-Pla A, Canals F, Saura C, Villanueva J, Circulating SOD2 Is a Candidate Response Biomarker for Neoadjuvant Therapy in Breast Cancer. Cancers (Basel), 14(16):(2022) [pubmed] |
Keyword List
submitter keyword: proteolysis-resistant proteins,SOD2, biomarker |
Contact List
Josep Villanueva |
contact affiliation | Vall d'Hebron Institute of Oncology (VHIO) |
contact email | jvillanueva@vhio.net |
lab head | |
Francesc Canals |
contact affiliation | Vall Hebron Institute of Oncology |
contact email | fcanals@vhio.net |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD032359
- Label: PRIDE project
- Name: Circulating SOD2 is a Response Biomarker for Neoadjuvant Therapy in Breast Cancer