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PXD032312-1

PXD032312 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTemporal Quantitative Proteomic Profiling of Murine Embryonic Heart Development
DescriptionComprehensive detail of the molecular mechanisms that govern heart development is essential for identifying the etiology of congenital heart disease. We used high-throughput quantitative proteomics to measure temporal changes in the cardiac proteome at eight critical stages of murine embryonic heart development. We identified more than 7,300 proteins, assessed global temporal changes in protein expression, identified cardiac protein interaction networks, and linked protein dynamics with molecular pathways. Using this dataset, we identified and defined a function for the mevalonate pathway in the regulation of embryonic cardiomyocyte proliferation and cell signaling. Overall, our proteomic datasets are an invaluable resource for studying molecular events that regulate embryonic heart development and that contribute to congenital heart disease.
HostingRepositoryPRIDE
AnnounceDate2023-04-06
AnnouncementXMLSubmission_2023-04-06_14:26:03.464.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLauraHerring
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-03-16 03:57:36ID requested
12023-04-06 14:26:03announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: TMT, development, quantitative proteomics,heart
Contact List
FrankConlon
contact affiliationDepartment of Biology, UNC-Chapel Hill
contact emailfrank_conlon@med.unc.edu
lab head
LauraHerring
contact affiliationUNC-Chapel Hill
contact emaillaura_herring@med.unc.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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