PXD031969 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Serum proteomics covid-19 vaccine |
Description | In the last two years, the coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a scientific and social challenge worldwide. Vaccines have been the most effective intervention for reducing virus transmission and disease severity. However, virus genetic variants are still circulating among vaccinated individuals with different symptomatology disease cases. Understanding the protective or disease associated mechanisms in vaccinated individuals is relevant to advance in vaccine development and implementation. To address this objective, serum protein profiles were characterized by quantitative proteomics and data analysis algorithms in four cohorts of vaccinated individuals uninfected and SARS-CoV-2 infected with asymptomatic, nonsevere and severe disease symptomatology. The results showed that immunoglobulins were the most overrepresented proteins in infected cohorts when compared to PCR-negative individuals. The immunoglobulin profile varied between different infected cohorts and correlated with protective or disease associated capacity. Overrepresented immunoglobulins in PCR-positive individuals correlated with protective response against SARS-CoV-2, other viruses, and thrombosis in asymptomatic cases. In nonsevere cases, correlates of protection against SARS-CoV-2 and HBV together with risk of myasthenia gravis and allergy and autoantibodies were observed. Patients with severe symptoms presented risk for allergy, chronic idiopathic thrombocytopenic purpura, and autoantibodies. The analysis of underrepresented immunoglobulins in PCR-positive compared to PCR-negative individuals identified vaccine-induced protective epitopes in various coronavirus proteins including the Spike receptor-binding domain RBD. Non-immunoglobulin proteins were associated with COVID-19 symptoms and biological processes. These results evidence host-associated differences in response to vaccination and the possibility of improving vaccine efficacy against SARS-CoV-2. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-14 |
AnnouncementXML | Submission_2022-10-14_14:45:46.297.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD031969 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | MargaritaVillar |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-03-01 10:14:53 | ID requested | |
⏵ 1 | 2022-10-14 14:45:47 | announced | |
2 | 2023-11-14 07:48:37 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD031969; |
Villar M, Urra JM, Artigas-Jer, ó, nimo S, Mazuecos L, Contreras M, Vaz-Rodrigues R, Rodr, í, guez-Del-R, í, o FJ, Gort, á, zar C, de la Fuente J, Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated Individuals. Molecules, 27(18):(2022) [pubmed] |
Keyword List
submitter keyword: COVID-19 |
Proteomic |
Vaccine |
Immunology |
Biomarker |
Contact List
MargaritaVillar |
contact affiliation | Proteomics Lab. IREC (CSIC-UCLM-JCCM) Spain |
contact email | margaritam.villar@uclm.es |
lab head | |
MargaritaVillar |
contact affiliation | University of Castilla- La Mancha |
contact email | margaritam.villar@uclm.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031969
- Label: PRIDE project
- Name: Serum proteomics covid-19 vaccine