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PXD031766-1

PXD031766 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse inner organ injury Peritomeum, Liver, Cecum
DescriptionInternal organs heal injuries with new connective tissue. However the cellular and molecular events, and the sources of this tissue, remain obscure. Here we tagged extracellular matrix around the mesothelium lining various mouse tissues: peritoneum, liver, and cecum, and applied various injury models. We discovered that preexisting matrix is transferred across organs into wounds. Using proteomics, genetic lineage-tracing and by selectively injuring juxtaposed organs, we demonstrate that the matrix tissue of origin likely dictates the final healing outcome: whether scarring or regeneration.
HostingRepositoryPRIDE
AnnounceDate2022-05-20
AnnouncementXMLSubmission_2022-05-20_07:31:18.694.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD031766
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterSafouane Kadri
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-21 02:40:05ID requested
12022-05-20 07:31:19announced
Publication List
Fischer A, Wannemacher J, Christ S, Koopmans T, Kadri S, Zhao J, Gouda M, Ye H, M, ü, ck-H, ä, usl M, Krenn PW, Machens HG, F, ä, ssler R, Neumann PA, Hauck SM, Rinkevich Y, Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nat Immunol, 23(4):518-531(2022) [pubmed]
Keyword List
submitter keyword: Mouse Peritomeum, Liver, Cecum LC-MS/MS
Contact List
Dr. Yuval Rinkevich
contact affiliationInstitute Regenerative Biology and Medicine, Helmholtz Zentrum München
contact emailyuval.rinkevich@helmholtz-muenchen.de
lab head
Safouane Kadri
contact affiliationHelmholtz-Muenchen
contact emailSafouane.kadri@helmholtz-muenchen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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