PXD031766

PXD031766 is an original dataset announced via ProteomeXchange.

Title	Mouse inner organ injury Peritomeum, Liver, Cecum
Description	Internal organs heal injuries with new connective tissue. However the cellular and molecular events, and the sources of this tissue, remain obscure. Here we tagged extracellular matrix around the mesothelium lining various mouse tissues: peritoneum, liver, and cecum, and applied various injury models. We discovered that preexisting matrix is transferred across organs into wounds. Using proteomics, genetic lineage-tracing and by selectively injuring juxtaposed organs, we demonstrate that the matrix tissue of origin likely dictates the final healing outcome: whether scarring or regeneration.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-20_07:31:18.694.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD031766
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Safouane Kadri
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-02-21 02:40:05	ID requested
⏵ 1	2022-05-20 07:31:19	announced

Fischer A, Wannemacher J, Christ S, Koopmans T, Kadri S, Zhao J, Gouda M, Ye H, M, ü, ck-H, ä, usl M, Krenn PW, Machens HG, F, ä, ssler R, Neumann PA, Hauck SM, Rinkevich Y, Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nat Immunol, 23(4):518-531(2022) [pubmed]

submitter keyword: Mouse Peritomeum, Liver, Cecum LC-MS/MS

Dr. Yuval Rinkevich
contact affiliation	Institute Regenerative Biology and Medicine, Helmholtz Zentrum München
contact email	yuval.rinkevich@helmholtz-muenchen.de
lab head
Safouane Kadri
contact affiliation	Helmholtz-Muenchen
contact email	Safouane.kadri@helmholtz-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD031766

PRIDE project URI

• PRIDE
  1. PXD031766
     1. Label: PRIDE project
     2. Name: Mouse inner organ injury Peritomeum, Liver, Cecum