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PXD031739-1

PXD031739 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffects on the lipid metabolism of Atlantic cod (Gadus morhua) after in vivo exposure with Ppar agonists
DescriptionLipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, the peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. Four Ppar subtypes from Atlantic cod (Gadus morhua) were recently cloned and characterized. However, the downstream regulatory role of Ppars in cod lipid metabolism is presently not well understood or described. Here we study the involvement of Atlantic cod Ppar subtypes in systemic regulation of lipid metabolism using the model agonists WY14,643, GW501516, and tetradecylthioacetic acid, employing a multiple omics approach after an in vivo exposure situation.
HostingRepositoryPRIDE
AnnounceDate2022-09-20
AnnouncementXMLSubmission_2022-09-20_05:58:08.579.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterOdd Andre Karlsen
SpeciesList scientific name: Gadus morhua (Atlantic cod); NCBI TaxID: 8049;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-17 04:17:07ID requested
12022-09-20 05:58:08announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Atlantic cod, WY14643, GW501516, tetradecylthioacetic acid, liver, TMT-proteomics
Contact List
Odd André Karlsen
contact affiliationDepartment of Biological Sciences University of Bergen Norway
contact emailodd.karlsen@uib.no
lab head
Odd Andre Karlsen
contact affiliationDepartment of Biology, University of Bergen, Norway
contact emailodd.karlsen@uib.no
dataset submitter
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Dataset FTP location
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