PXD031639 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Proteome and Transcriptome of Stress Granules and P-Bodies during Human T Lymphocytes Activation |
Description | Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their immune functions under regulatory mechanisms involving SGs and PBs. However, the impact of T cell activation on such complexes, in term of formation, constitution and relationship remains unknown. Here, by combining proteomic, transcriptomic and immunofluorescence approaches, we simultaneously characterized the SGs and PBs from primary human T lymphocytes pre- and post-stimulation. The proteomes and transcriptomes of SGs and PBs were identified, unveiling an unanticipated molecular and functional complementarity. Notwithstanding, these granules keep distinct spatial organizations and abilities to interact with mRNAs. This comprehensive characterization of the RNP granule proteomic and transcriptomic landscapes provides a unique resource for future investigations on SGs and PBs in T lymphocytes. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:55:40.117.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Don-Marc Franchini |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-13 12:59:09 | ID requested | |
1 | 2023-03-10 11:25:06 | announced | |
⏵ 2 | 2023-11-14 08:55:40 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: human T lymphocytes,ribonucleoprotein granules, proteome |
Contact List
Camille Laurent |
contact affiliation | Cancer Research Center of Toulouse (CRCT) 2 Avenue Hubert Curien 31037 Toulouse |
contact email | laurent.c@chu-toulouse.fr |
lab head | |
Don-Marc Franchini |
contact affiliation | Cancer Research Center of Toulouse (CRCT) |
contact email | don-marc.franchini@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031639
- Label: PRIDE project
- Name: The Proteome and Transcriptome of Stress Granules and P-Bodies during Human T Lymphocytes Activation