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PXD031572

PXD031572 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics analysis of physiological effect of ZBTB16 (PLZF) on osteogenic differentiation of human valve interstitial cells (VICs) by DDA PASEF on TimsToF Pro
DescriptionDuring fundamental proteotranscriptomic analysis of human valve interstitial cells (VICs) osteogenic differentiation, we revealed ZBTB16 (PLZF) as one of the most upregulated proteins. Thus, to investigate its physiological role in VICs osteogenic differentiation we performed its overexpression by lentiviral transduction with subsequent proteomics analysis. Despite obvious PLZF overexpression and its reinforcing effect on osteogenic differentiation, we revealed surprisingly small amount of differentially expressed proteins that assumed to be the targets of PLZF.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:54:51.956.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD031572
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterArseniy Lobov
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-10 13:07:15ID requested
12022-10-21 03:30:54announced
22023-11-14 08:54:52announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD031572;
Keyword List
submitter keyword: ZBTB16
PLZF
osteogenic differentiation
valve interstitial cells
PASEF
TimsToF Pro
Contact List
Anna B. Malashicheva
contact affiliationLaboratory of regenerative biomedicine, Institute of Cytology of the Russian Academy of Science
contact emailamalashicheva@gmail.com
lab head
Arseniy Lobov
contact affiliationEmmanuel Levy Lab, Dept. of Chemical and Structural Biology, Weizmann Institute of Science
contact emailarseniylobov@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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