PXD031403 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis underlying the impact of early life nutrition on the molecular control of testicular development in the young bull calf. |
Description | It has been established that enhanced early life nutrition progresses sexual development in the bull calf through neuroendocrine signalling via the hypothalamic-pituitary-testicular axis. However, the underlying molecular mechanisms regulating this process have not been fully elucidated. This study measured the impact of contrasting feeding regimes in the first 12 wk of life, known to impact age at puberty, on the proteomic landscape of the testes of bull calves. Holstein bull calves with a mean (±SD) bodyweight and age of 48.8 (± 5.3) kg and 17.5 (± 2.8) days, were designated to high (HI; n=10) or moderate (MOD; n=10) dietary groups, with diets designed to provoke growth rates of 1.0 and 0.5 kg/day, respectively. At 12 wk of age, all calves were euthanized, and testes parenchyma harvested. HI calves were heavier at slaughter (112.4 v 88.7 (2.98) kg, P<0.001), and had a greater average daily gain (ADG) of (0.88 v 0.58 kg, P<0.001). The turquoise network from the protein analyses contained the protein CDH13 which is involved in testes development. Gene ontology analysis of the turquoise network revealed enrichment of genes with functions related to cholesterol biosynthesis, IGF-1 signalling, insulin receptor/secretion signalling, androgen signalling and Sertoli cell junction signalling. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-30 |
AnnouncementXML | Submission_2022-08-30_02:00:42.412.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stephen Coen |
SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; |
ModificationList | deamidated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-02-03 03:41:39 | ID requested | |
⏵ 1 | 2022-08-30 02:00:42 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Nutrition, testes, protein, bull calf, early life |
Contact List
David Kenny |
contact affiliation | Animal Bioscience Department, Teagasc (lab head) |
contact email | david.kenny@teagasc.ie |
lab head | |
Stephen Coen |
contact affiliation | Teagasc |
contact email | scoen101@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031403
- Label: PRIDE project
- Name: Proteomic analysis underlying the impact of early life nutrition on the molecular control of testicular development in the young bull calf.