PXD031349 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Longitudinal proteomics study of serum changes after allogeneic hematopoietic stem cell transplantation reveals potential markers of metabolic complications related to acute graft-versus-host disease |
Description | Even though hematopoietic stem cell transplantation (HSCT) allows successful treatment for many malignant and non-malignant disorders, its curative potential remains limited by severe side effects, including infections and other transplant-related complications such as graft-versus-host disease (GvHD). This study examined changes in serum proteome via high-performance two-dimensional gel electrophoresis (2-DE) during HSCT to search for diagnostic biomarkers for post-HSCT complications. Serum samples were collected from five acute leukaemia patients (n = 5) prior to HSCT (week 0) and weekly after HSCT for eight weeks (week 1–8). A natural cubic spline with a single internal knot at the median HSCT time (t = 21 days after treatment) was fit to each spot’s log-percentage volume contribution (%vol) and 39 spots were determined to be significantly changed due to HSCT. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:29:33.435.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sing Ying Wong |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-31 00:58:21 | ID requested | |
1 | 2022-10-14 11:09:58 | announced | |
⏵ 2 | 2023-11-14 07:29:34 | announced | 2023-11-14: Updated project metadata. |
Publication List
Wong SY, Kato S, Rodenburg F, Tojo A, Hayashi N, Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD. Sci Rep, 12(1):14002(2022) [pubmed] |
Keyword List
submitter keyword: Human, 2-DE, serum, LC-MS/MS |
Contact List
Nobuhiro Hayashi |
contact affiliation | School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan |
contact email | nhayashi@bio.titech.ac.jp |
lab head | |
Sing Ying Wong |
contact affiliation | Postdoctoral researcher, Hayashi Lab, Graduate School of Life Science and Technology, Tokyo Institute of Technology, Japan |
contact email | wong.s.ac@m.titech.ac.jp |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031349
- Label: PRIDE project
- Name: Longitudinal proteomics study of serum changes after allogeneic hematopoietic stem cell transplantation reveals potential markers of metabolic complications related to acute graft-versus-host disease