PXD031349

PXD031349 is an original dataset announced via ProteomeXchange.

Title	Longitudinal proteomics study of serum changes after allogeneic hematopoietic stem cell transplantation reveals potential markers of metabolic complications related to acute graft-versus-host disease
Description	Even though hematopoietic stem cell transplantation (HSCT) allows successful treatment for many malignant and non-malignant disorders, its curative potential remains limited by severe side effects, including infections and other transplant-related complications such as graft-versus-host disease (GvHD). This study examined changes in serum proteome via high-performance two-dimensional gel electrophoresis (2-DE) during HSCT to search for diagnostic biomarkers for post-HSCT complications. Serum samples were collected from five acute leukaemia patients (n = 5) prior to HSCT (week 0) and weekly after HSCT for eight weeks (week 1–8). A natural cubic spline with a single internal knot at the median HSCT time (t = 21 days after treatment) was fit to each spot’s log-percentage volume contribution (%vol) and 39 spots were determined to be significantly changed due to HSCT.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:29:33.435.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sing Ying Wong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-31 00:58:21	ID requested
1	2022-10-14 11:09:58	announced
⏵ 2	2023-11-14 07:29:34	announced	2023-11-14: Updated project metadata.

Wong SY, Kato S, Rodenburg F, Tojo A, Hayashi N, Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD. Sci Rep, 12(1):14002(2022) [pubmed]

submitter keyword: Human, 2-DE, serum, LC-MS/MS

Nobuhiro Hayashi
contact affiliation	School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
contact email	nhayashi@bio.titech.ac.jp
lab head
Sing Ying Wong
contact affiliation	Postdoctoral researcher, Hayashi Lab, Graduate School of Life Science and Technology, Tokyo Institute of Technology, Japan
contact email	wong.s.ac@m.titech.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD031349

PRIDE project URI

• PRIDE
  1. PXD031349
     1. Label: PRIDE project
     2. Name: Longitudinal proteomics study of serum changes after allogeneic hematopoietic stem cell transplantation reveals potential markers of metabolic complications related to acute graft-versus-host disease