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PXD031193-2

PXD031193 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChronic stress causes striatal disinhibition mediated by SOM-interneurons
DescriptionChronic stress is a major triggering factor for neuropsychiatric disorders including obsessive-compulsive disorder (OCD), a mental health condition characterized by motor stereotypies and striatal overactivation. However, the mechanisms at the cell- and microcircuit-level through which stress triggers motor symptoms is currently unknown. Here, we report that chronic stress (CS) in mice alters dorsomedial striatum (DMS) function, by affecting GABAergic interneuron populations and somatostatin-positive (SOM) interneurons in particular. Specifically, we show that CS impairs communication between SOM interneurons and medium spiny neurons, promoting striatal overactivation / disinhibition and increased motor output. Using probabilistic machine learning for analyzing animal behavior we further demonstrate that in vivo chemogenetic manipulation of SOM interneurons in DMS modulates motor phenotypes in stressed mice. Altogether, we propose a causal link between dysfunction of striatal SOM interneurons and motor symptoms in stress-related neuropsychiatric disorders.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:54:49.342.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCátia Santa
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListS-carboxamidoethyl-L-cysteine
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-24 02:48:25ID requested
12022-12-13 10:11:27announced
22023-11-14 08:54:49announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: striatum, SWATH-MS, chronic stress
Contact List
Bruno Manadas
contact affiliationCenter for Neuroscience and Cell Biology
contact emailbmanadas@gmail.com
lab head
Cátia Santa
contact affiliationCenter for Neuroscience and Cell Biology
contact emailcatiajmsanta@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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