PXD031029-1
PXD031029 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Nuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease |
Description | We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues in CDYL KO versus parental WT 9-12 cells (control) using high-resolution liquid chromatography tandem mass spectrometry (LC-MS/MS)-based proteomics analysis |
HostingRepository | iProX |
AnnounceDate | 2022-01-17 |
AnnouncementXML | Submission_2022-01-17_03:51:15.033.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xinyi Cao |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-01-17 03:50:50 | ID requested | |
⏵ 1 | 2022-01-17 03:51:15 | announced | |
2 | 2023-09-06 23:59:49 | announced | 2023-09-07: Update publication information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CDYL, Histone Crotonylation, WT9-12 cells |
Contact List
Yupeng Chen | |
---|---|
contact affiliation | Tianjin Medical University |
contact email | ychen@tmu.edu.cn |
lab head | |
Xinyi Cao | |
contact affiliation | Tianjin Medical University |
contact email | xy_cao@tmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |