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PXD031027

PXD031027 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlerabbit haemorrhagic disease virus (RHDV) infected rabbit liver proteome
DescriptionRabbit haemorrhagic disease virus (RHDV) belongs to the family Caliciviridae, genus Lagovirus and is used in Australia as a biocontrol tool to keep the population of european rabbits low. This virus has a positive-sense single-stranded RNA genome that encodes structural (capsid) and non-structural proteins. Due to the lack of an established cell culture system for this virus, some of the non-structural proteins are yet awaiting characterisation and their function is unknown. This work attempted to characterise the process of RHDV infection and identify pathways that alterate in RHDV-infected rabbit liver at the proteome level. Young rabbits were infected with RHDV2 (genotype GI.1bP-GI.2) and humanely killed 24 hours post-infection. 25% liver homogenates were prepared in RNAlater buffer and stored at -20C. Uninfected rabbit liver samples served as a control. Samples from three RHDV2-infected animals (K375, K376, K378) and three uninfected animals (K3, K14, K12) were used in this study.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:01:32.858.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterElena Smertina
SpeciesList scientific name: Oryctolagus cuniculus cuniculus; NCBI TaxID: 568996;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-17 01:24:57ID requested
12022-10-13 20:30:53announced
22023-11-14 08:01:33announced2023-11-14: Updated project metadata.
Publication List
Smertina E, Carroll AJ, Boileau J, Emmott E, Jenckel M, Vohra H, Rolland V, Hands P, Hayashi J, Neave MJ, Liu JW, Hall RN, Strive T, Frese M, Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization. Front Microbiol, 13():923256(2022) [pubmed]
Keyword List
submitter keyword: liver, proteome,RHDV, rabbit
Contact List
Tanja Strive
contact affiliationCSIRO Black Mountain, Australia
contact emailtanja.strive@csiro.au
lab head
Elena Smertina
contact affiliationUniversity of Canberra/CSIRO
contact emailelena.smertina@csiro.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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Repository Record List
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