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PXD030995-1

PXD030995 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMetabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L
DescriptionThe transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled to reversible changes in energy metabolism with key implications for life-long NSPC self-renewal and neurogenesis. How this metabolic plasticity is ensured between NSPC activity states is unclear. We find that a state-specific rewiring of the mitochondrial proteome by the i-AAA peptidase YME1L is required to preserve NSPC self-renewal. YME1L controls the abundance of numerous mitochondrial substrates in quiescent NSPCs, and its deletion activates a differentiation program characterized by broad metabolic changes causing the irreversible shift away from a fatty acid oxidation-dependent state. Conditional Yme1l deletion in adult NSPCs in vivo results in defective self-renewal and premature differentiation, ultimately leading to NSPC pool depletion. Our results disclose an important role for YME1L in coordinating the switch between metabolic states of NSPCs and suggest that NSPC fate is regulated by compartmentalized changes in protein network dynamics.
HostingRepositoryPRIDE
AnnounceDate2022-02-10
AnnouncementXMLSubmission_2022-02-10_00:14:15.543.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPrerana Wagle
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-16 13:11:24ID requested
12022-02-10 00:14:15announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: neural stem cells
Mitochondria
metabolic rewiring
mitochondrial proteome
mitochondrial dynamics
adult neurogenesis
Self-renewal
YME1L
OMA1
Contact List
Matteo Bergami
contact affiliationCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
contact emailmatteo.bergami@uk-koeln.de
lab head
Prerana Wagle
contact affiliationCECAD Research Center
contact emailproteomics-facility@uni-koeln.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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