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PXD030940-1

PXD030940 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study
DescriptionIn this study, resistance of Klebsiella pneumoniae (K. pneumoniae) to PB was induced by passaging in serial concentrations of PB. This study employed TMT-labeled quantitative proteomics and LC-MS/MS metabolomics analysis to investigate the key biological processes associated with PB resistance in K. pneumoniae. A total of 315 differentially expressed proteins (DEPs) were identified, of which 133 were upregulated, and 182 were downregulated in the PB resistant K. pneumoniae. Metabolomics data demonstrated that 23 metabolites were significantly upregulated in PB resistant K. pneumoniae, 5 were downregulated.
HostingRepositoryPRIDE
AnnounceDate2022-01-24
AnnouncementXMLSubmission_2022-01-24_08:33:16.555.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXinyi Chen
SpeciesList scientific name: Klebsiella pneumoniae LCT-KP289; NCBI TaxID: 1352933;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-13 07:55:32ID requested
12022-01-24 08:33:16announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, metabolomics, Klebsiella pneumoniae, polymyxin B resistance, membrane remodeling
Contact List
Min Wang
contact affiliationDepartment of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China
contact emailwangmin0000@csu.edu.cn
lab head
Xinyi Chen
contact affiliationThe Second Xiangya Hospital of Central South University
contact emailcxy208211093@csu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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