PXD030940

PXD030940 is an original dataset announced via ProteomeXchange.

Title	Cell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study
Description	In this study, resistance of Klebsiella pneumoniae (K. pneumoniae) to PB was induced by passaging in serial concentrations of PB. This study employed TMT-labeled quantitative proteomics and LC-MS/MS metabolomics analysis to investigate the key biological processes associated with PB resistance in K. pneumoniae. A total of 315 differentially expressed proteins (DEPs) were identified, of which 133 were upregulated, and 182 were downregulated in the PB resistant K. pneumoniae. Metabolomics data demonstrated that 23 metabolites were significantly upregulated in PB resistant K. pneumoniae, 5 were downregulated.
HostingRepository	PRIDE
AnnounceDate	2022-01-24
AnnouncementXML	Submission_2022-01-24_08:33:16.555.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinyi Chen
SpeciesList	scientific name: Klebsiella pneumoniae LCT-KP289; NCBI TaxID: 1352933;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-13 07:55:32	ID requested
⏵ 1	2022-01-24 08:33:16	announced

Dataset with its publication pending

submitter keyword: proteomics, metabolomics, Klebsiella pneumoniae, polymyxin B resistance, membrane remodeling

Min Wang
contact affiliation	Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China
contact email	wangmin0000@csu.edu.cn
lab head
Xinyi Chen
contact affiliation	The Second Xiangya Hospital of Central South University
contact email	cxy208211093@csu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD030940

PRIDE project URI

• PRIDE
  1. PXD030940
     1. Label: PRIDE project
     2. Name: Cell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study