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PXD030896-1

PXD030896 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of FAO deficient mouse model
DescriptionObjective: Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional demands and substrate availability by modulating muscle fiber size and type. The concept of muscle fiber type relates to its contractile (slow or fast) and metabolic (glycolytic or oxidative) properties. Here, we tested whether disruptions in muscle oxidative catabolism are sufficient to prompt parallel adaptations in energetics and contractile protein composition. Conclusion: The loss of mitochondrial long-chain fatty acid oxidation elicits an adaptive response involving conversion of oxidative muscle towards a metabolic profile that resembles a glycolytic muscle but that is not accompanied by changes in myosin heavy chain isoforms. These data suggest that shifts in muscle catabolism are not sufficient to drive shifts in the contractile apparatus but are sufficient to drive adaptive changes in metabolic properties.
HostingRepositoryjPOST
AnnounceDate2022-01-12
AnnouncementXMLSubmission_2022-01-11_11:52:33.385.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJessica Ellis
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListL-methionine sulfoxide; TMT6plex reporter+balance reagent N-acylated residue; TMT6plex reporter+balance reagent acylated N-terminal; S-carboxamidomethyl-L-cysteine
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-11 11:52:30ID requested
12022-01-11 11:52:33announced
22022-09-18 02:14:15announced2022-09-18: Updated FTP location.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: fatty acid oxidation, skeletal muscle, CPT2, mitochondria
Contact List
Jessica M. Ellis
lab head
Jessica Ellis
contact affiliationEast Carolina University
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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